وارد شوید
Department of Regenerative Medicine and Biotechnology in Wound Healing
The Research Department for Regenerative Medicine and Biotechnology in Wound Repair encompasses three principal pillars: Biotechnology, Biomaterials and Tissue Engineering, and Biomedical Science. The department is dedicated to advancing and integrating state-of-the-art life-science technologies to enhance wound and tissue repair.
- Engineering of advanced biopolymers and biomaterials, and their interdisciplinary clinical applications.
- Development and production of biological, synthetic, and smart wound dressings for use in regenerative and reconstructive medicine.
- Microencapsulation for drug-delivery systems.
- Development and production of recombinant proteins to facilitate regeneration of damaged tissues, accelerate wound healing, and enable related biotechnological products.
- Identification and characterization of genes, cellular–molecular signaling pathways, and key proteins implicated in wound and tissue repair.
- Cell therapy and the application of cell- and tissue-derived products effective in wound and tissue repair.
- To organize and advance foundational and advanced technologies across biotechnology, biomedical science, and tissue engineering.
- To develop and disseminate technical knowledge and innovative techniques for wound repair, with particular emphasis on chronic and treatment-resistant wounds.
- To establish standards and conduct clinical trials, especially within regenerative and reconstructive medicine.
- To transfer acquired knowledge and indigenously developed technologies to industry (knowledge enterprises, investment funds, and other healthcare centers).
- Scientific consulting and collaboration with clinical centers, research institutes, universities, and knowledge enterprises.
- Supervision of student theses in disciplines aligned with the Department’s activities.
- Execution of preclinical and clinical studies.
- Generation, development, and transfer of technical knowladge in regenerative and reconstructive medicine.
- Organization of national and international courses, symposia, congresses, and workshops.
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Full - Time Faculty
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Researchers
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Research Associates
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Publications
- • How do swim-up and Density Gradient Centrifugation methods affect sperm biological parameters, DNA fragmentation, and separation of spermatozoa containing X and Y chromosomes?
• How does serum starvation affect the morphological, biochemical, and content heterogeneity of exosomes extracted from human adipose-derived mesenchymal stem cells?
• Morphological, chemical, and functional characteristics of nanoparticles derived from human placental extract, applications in regenerative medicine
• Morphological characteristics, mitochondrial oxidoreductase activity, and vascularization of human adipose tissues pre-and post-xenotransplantation into BALB/c female nude mice
• The quality and quantity of nanoparticles extracted from human adipose tissue-derived mesenchymal stem cells
• New therapeutic strategy for increasing pregnancy rate in clomiphene citrate-resistant PCOS
• Comparative effects of hypoxia and serum deprivation on the morphological, structural, chemical, biological, and functional characteristics of exosomes from adipose-derived
• The Role of Stem Cell Polyphenols in Wound Healing: A Narrative Review
- • Effect of Intra-ovarian Injection of Mesenchymal Stem Cells or its Conditioned Media on Repeated OPU-IVEP Outcomes in Jersey Heifers and Its Relationship with Follicular Fluid Inflammatory Markers
• Identification and Manipulation of Spermatogonial Stem Cells with the Aim of Inducing Spermatogenesis in Vitro
• Efficient procedure for human adipose tissue cryopreservation without specialized freezing equipment
• Characterization of an engineered ACE2 protein for its improved biological features and its transduction into MSCs: A novel approach to combat COVID-19 infection
• Cell immortality: in vitro effective techniques to achieve and investigate its applications and challenges
• Stem Cell Perspective for Regenerative Wound Healing: From Biology toward Future Clinical
• The Role of Plant-Derived Stem Cell Polyphenols in Wound Healing: A Narrative Review
• TERMC 2024: Technical advances in tissue repair using AceCell Plus®: A three-dimensional decellularized amniotic membrane scaìold loaded with activated allogeneic mesenchymal stem cells
• Unveiling Novel Biomarkers: A Clinical Study of miR-146a and miR-222 in the Diagnosis and Treatment of Polycystic Ovary Syndro
• Innovative Approaches for Stabilizing Recombinant Growth Factors in Diabetic Foot Ulcer Treatment
• Wound healing and distribution of cell cycle phase in venous ulcer
• Study Of MSC-GFP+ Localization And Fate In Cardiac Micro-tissue
• Investigation of common pathways and genes in Glioma
• Mesenchymal Stem Cell Nanofibers for Skin Regeneration and Wound Healing
• Human Three-Dimensional Acellular Amniotic Membrane Containing Adipose Tissue-Derived Mesenchymal Stem Cells; How Deep Is The Penetration of Allogenic Stem Cells into The Scaffold?
• combination of two stem cell therapy and tissue engineering technologies, the
• Efficient preservation of human adipose tissue after cryopreservation
• KDM6A Over-Expression Attenuated Epithelial- Mesenchymal Transition and Induced Mesenchymal-Epithelial Transition in Hepatocellular Carcinoma Cells
• The Potential of Oncolytic Virus as A Therapeutic Strategy for Glioblastoma Treatment (2D and 3D Model)
- The story of melanocyte: a long way from bench to bedside
- Effectiveness Photobiomodulation therapy on reproduction, colonization and immigration of fibroblast cells in normal and diabetic conditions
- Safety and Efficacy of Autologous Melanocyte/Keratinocyte Transplantation in Patients with Refractory Stable Vitiligo
- Breast cancer tumor microenvironment affects Treg/IL-17-producing Treg/Th17 cell axis: Molecular and therapeutic perspectives
- Mutual interaction of lncRNAs and epigenetics: focusing on cancer
- Purinergic P2X7 Receptor as a Potential Targeted Therapy for COVID-19-associated Lung Cancer Progression
- A Historical Overview of the Neurological Disorders Associated with Gastrointestinal Ailments from the Viewpoint of Avicenna
- Current concepts of microRNA-mediated regulatory mechanisms in human pulp tissue-derived stem cells: a snapshot in the regenerative dentistry
- Evaluation of Sinensetin Derived from Flavonoids-Rich Orthosiphon Stamineus as a New Radiosensitizer in MDA-MB-231 and T47D as Breast Cancer Cell Line
- In Vitro Radiosensitization of T47D and MDA-MB-231 Breast Cancer Cells with the Neoflavonoid Dalbergin
- Zn(II) porphyrin–encapsulated MIL-101 for photodynamic therapy of breast cancer cells
- Application of Maggot Debridement Therapy on Infected Wounds of Newborns: A Case Series in Iran
- Effect of Intra-ovarian Injection of Mesenchymal Stem Cells or its Conditioned Media on Repeated OPU-IVEP Outcomes in Jersey Heifers and Its Relationship with Follicular Fluid Inflammatory Markers
- Introduction to Cartilage Tissue: Development, Structure, and Functions
- Foam nanocomposite based on alginate/ gelatin/zeolite for wound dressing: in vitro study
- Abdominal obesity may play a significant role in the augmentation of inflammation in women with polycystic ovary syndrome
- Aspirin and aloe-emodin, as two anti-inflammatory compounds, do not change the healthy adhesive and proliferative phenotype of human endometrial stromal cells
- Skin wound tissue engineering: with focus on stem cell-based therapeutic approaches
- Preparation of Polylactic Acid/Hyaluronic Acid Electrospun Wound Dressings Containing Niacinamide
- Lab scale production of recombinant platelet-derived growth factor-BB homodimer (PDGF-BB) in microbial expression system for wound healing applications
- In Vitro Radiosensitization of T47D and MDA-MB-231 Breast Cancer Cells with the Neoflavonoid Dalbergin
- Cellular Therapy: The Hope for Covid-19
- Osteogenic Differentiation of Menstrual Blood-Derived Stem Cells by Optogenetics
- Evaluation of Sinensetin derived from flavonoids-rich Orthosiphon Stamineus as a new radiosensitizer in breast cancer cell lines
- In Vitro Radiosensitization of T47D and MDA-MB-231 Breast Cancer Cells with the Neoflavonoid Dalbergin
- Overexpression of miR-490-5p/miR-490-3p Potentially Induces IL-17-Producing T Cells in Patients With Breast Cancer
- CML derived exosomes promote tumor favorable functional performance in T cells
- Evaluation of the Synergistic Effects of Ciprofloxacin and Low-Power Laser on Apoptosis, Cell Viability, and Reactive Oxygen Species Levels in Skin Cancer
- Study of Low level laser in citrus peel polyphenolic extract on biological changes of CHO and Hela cells
- Gene expression and in vitro pharmacogenetic studies of dopamine and serotonin gene receptors in tuberculosis
- The related miRNAs involved in doxorubicin resistance or sensitivity of various cancers: an update
- Molecular Imaging in Cancer Studies: A Review
- “Angioregulatory microRNAs in breast cancer: Molecular mechanistic basis and implications for therapeutic strategies”
- Evaluation of the effect of low-level laser irradiation on viability and ROS production in human hair follicle stem cells
- Exploring Transcriptional Relationships Implicated in Autism and Inflammatory Bowel Diseases Using Systems Biology Approaches
- Optogenetic Stimulation of Primary Cardiomyocytes Expressing ChR2
- Significance of exosomes in covid-19 pathogenesis and therapy
- The state of the art of biomedical applications of optogenetics
- Ultrasound and Sonogenetics: A New Perspective for Controlling Cells with Sound
- Plasma Levels of MicroRNA-146a-5p, MicroRNA-24-3p, and MicroRNA-125a-5p as Potential Diagnostic Biomarkers for Rheumatoid Arthris
- An in vitro model for investigation of vitamin A effects on wound healing
- Biological Impacts of MicroRNAs in Covid-19: Implications for Anti-Viral miRNA-Based Therapies
- Concomitant overexpression of mir-182-5p and mir-182-3p raises the possibility of IL-17–producing Treg formation in breast cancer by targeting CD3d, ITK, FOXO1, and NFATs: A meta-analysis and experimental study
- Effect of rutin as flavonoid compound on photodynamic inactivation against P. aeruginosa and S. Aureus
- Evaluation of serotonin receptors (5HTR2A and 5HTR3A) mRNA expression changes in tumor of breast cancer patients
- Expression of miR-1290 and Its Target Genes THBS1 and DKK3 in Colorectal Cancer Patients
- Gold Nanoparticles Conjugated L- lysine for Improving Cisplatin Delivery to Human Breast Cancer Cells
- JAK Inhibition as a New Treatment Strategy for Patients with COVID-19
- Nanoformulation-Based Antiviral Combination Therapy for Treatment of COVID-19
- Network Analysis of Common Genes and Transcriptional Factors between Celiac Disease and Inflammatory Bowel Diseases
- سونوژنتیک موری بر مفاهیم و کاربردها
- ویروس کرونا گذشته حال و آینده محتمل
- افزایش زنده مانایی سلول های بنیادی فولیکول موی موش صحرایی با استفاده از نور لیزر کم توان
- Correlation between Expression of hsa-miR-490-5p and NFAT5 in Peripheral Blood Mononuclear Cells Obtained from Breast Cancer Patients
- MicroRNA Promoter Methylation in Colorectal Cancer
- Modulation of cardiac optogenetics by vitamin A
- Investigation of combined photodynamic and radiotherapy effects of gallium phthalocyanine chloride on MCF‑7 breast cancer cells
- Quorum-sensing-regulated virulence factors in Pseudomonas aeruginosa are affected by sub-lethal photodynamic inactivation
- Angioregulatory microRNAs in Colorectal Cancer
- Expression profiling of matrix metalloproteinase in adipose-derived stem cells under simulated microgravity condition
- Evaluation of Th1/Th2 Lymphocyte Balance in Peripheral Blood Mononuclear Cells of Patients with Hashimoto’s Thyroiditis
- Application of a collagen matrix dressing on a neuropathic diabetic foot ulcer: a randomised control trial
- Evaluation of expression of miR-182-3p in blood circulation of patients with breast cancer.
- The expression of Hsa-miR-490 in peripheral blood circulation of patients with breast cancer.
- Herbal Medicine Efficiency in Wound Healing.
- Alteration of cellular and immune‐related properties of bone marrow mesenchymal stem cells and macrophages by K562 chronic myeloid leukemia cell derived exosomes
- Preventive effects of oxytocin and oxytocin receptor in breast cancer pathogenesis
- Sub-lethal antimicrobial photodynamic inactivation: an in vitro study on quorum sensing-controlled gene expression of Pseudomonas aeruginosa biofilm formation
- Treatment of striae distensae using fractional ablative CO2 laser in skin types II-IV: a retrospective case series study
- Simulated Microgravity Condition Alters the Gene Expression of some ECM and Adhesion Molecules in Adipose Derived Stem Cells
- DRD2 Dopamine Receptor and IL-1β Gene Expression Changes Involved in Wound Healing in Type 2 Diabetic Patients with Foot Ulcer
- بررسی تأثیر لیزر الکساندریت برروی بیماران با سندرم پلی کیستیک تخمدان و بدون سندرم پلی کیستیک تخمدان
- نقش پروتئینها و عوامل مؤثر در ترمیم زخم
- A Comparative Study of 660 nm Low-Level Laser and Light Emitted Diode in Proliferative Effects of Fibroblast Cells
- Association of the gene expression variation of tumor necrosis factor-α and expressions changes of dopamine receptor genes in progression of diabetic severe foot ulcers
- Expression and Secretion of Cyan Fluorescent Protein (CFP) in B. subtilis using the Chitinase Promoter from Bacillus pumilus SG2
- Eff ect of Simulated Microgravity Conditions on Diff erentiation of Adipose Derived Stem Cells towards Fibroblasts Using Connective Tissue Growth Factor
- Photobiomodulation leads to enhanced radiosensitivity through induction of apoptosis and autophagy in human cervical cancer cells
- The diversity in the expression profile of caveolin II transcripts, considering its new transcript in breast cancer.
- ovel Epigenetic Controlling of Hypoxia Pathway Related to Overexpression and Promoter Hypomethylation of TET1 and TET2 in RPE Cells
- Simulated microgravity effects on cell cycle in adipose derived stem cells
- Interaction study of Gold nanorods with Chondriotinase ABC I to design drug nanocarrier systems for curing spinal cord injuries.
- بررسی اثر Fractional Ablative co2 در کاهش استریای بارداری در بیماران مبتلا به استریای بارداری
- Production of trypsin enzyme with research, industrial, and clinical applications at the laboratory scale.
- Evaluation of the safety and efficacy of using an acellular amniotic membrane scaffold containing adipose-derived mesenchymal stem cells (AceCell Plus®) in the treatment of chronic diabetic wounds.
- Optimization of adipose tissue cryopreservation protocols using different cryoprotectants.
- Design of a cryopreservation kit for adipose tissue containing protective cryoprotectants to preserve the structural and functional properties of adipose tissue.
- Production of biological products based on the amniotic membrane.
- Production of raw hyaluronic acid.
- Investigation of quantitative and qualitative characteristics of nanoparticles extracted from adipose-derived mesenchymal stem cells for use in regenerative and reparative medicine.
- Production of recombinant protein Interleukin-2 (IL-2) with pharmaceutical applications at the laboratory scale.
- Extraction of human placenta extract and derived nanoparticles for applications in regenerative and reparative medicine.
- Production of PDGF-BB homodimer (Platelet-Derived Growth Factor-BB) using recombinant DNA technology in a prokaryotic expression system at the laboratory scale.